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Diisopropylethylamine → HCID 86742360, 화합물

HRID 35274
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인쇄 미리보기

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HRID 35274 반응식
Cl.Cl.[CH3:3][N:4]([CH2:22][CH2:23][C:24]([NH2:26])=[NH:25])[C:5]([C:7]1[NH:8][CH:9]=[C:10]([N:12]([CH3:21])[C:13]([C:15]2[NH:16][CH:17]=[C:18]([NH2:20])[CH:19]=2)=[O:14])[CH:11]=1)=[O:6].C(N(C(C)C)CC)(C)C.[Cl:36]C1C=C(Cl)C(Cl)=CC=1[CH2:45][N:46]([N:50]=[O:51])[C:47](=O)[O-:48]>CN(C=O)C>[ClH:36].[CH3:3][N:4]([CH2:22][CH2:23][C:24]([NH2:26])=[NH:25])[C:5]([C:7]1[NH:8][CH:9]=[C:10]([N:12]([CH3:21])[C:13]([C:15]2[NH:16][CH:17]=[C:18]([NH:20][C:47]([N:46]([CH3:45])[N:50]=[O:51])=[O:48])[CH:19]=2)=[O:14])[CH:11]=1)=[O:6]
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참가 물질

5

반응물 3

HCID 81531DiisopropylethylamineHCID 70419786HCID 70419786, 화합물HCID 867423612,4,5-trichlorophenyl-N-methyl-N-nitrosocarbamate

생성물 1

HCID 86742360HCID 86742360, 화합물수율 55.3%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매2회

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온도
0 °C

실험 절차

To an ice-cooled solution of β-[N-methyl-4-(N-methyl-4-aminopyrrole-2-carboxamido)pyrrole-2-carboxamido]propionamidine dihydrochloride (0.404 g) in 5 ml of DMF and 320 mg of 2,4,5-trichlorophenyl-N-methyl-N-nitrosocarbamate [prepared according to J. Med. Chem. 25, 178 (1982)], a solution of diisopropylethylamine (0.164 ml) in 8 ml of DMF was added dropwise. The resulting solution was stirred 1 hour at 0° C. The reaction mixture was concentrated under vacuum and the residue was purified by column chromatography to yield 251 mg of β-[N-methyl-4-[N-methyl-4-(3 -methyl-3-nitrosoureido)pyrrole-2-carboxamido]pyrrole-2-carboxamido]propionamidine hydrochloride.

후처리

  1. concentrationThe reaction mixture was concentrated under vacuum
  2. customthe residue was purified by column chromatography

출처 및 근거

ORD 기록
ord-d2cd7f175f1c4ecc916506a7965483ea
출처 데이터셋
uspto-grants-1988_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04766142

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