4-Methylmorpholine → 4-Chloro-2-methoxybenzaldehyde
반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][OH:9])=[C:4]([O:10][CH3:11])[CH:3]=1.CN1CCOCC1>C(Cl)Cl.[Ru]([O-])(=O)(=O)=O.C([N+](CCC)(CCC)CCC)CC>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[O:9])=[C:4]([O:10][CH3:11])[CH:3]=1참가 물질
5
실험 절차
In methylene chloride (80 ml) was dissolved (4-chloro-2-methoxyphenyl)methanol (3.69 g). Under ice cooling, molecular sieve 4A (4.57 g), N-methylmorpholine (2.81 g) and tetra-n-propylammonium perruthenate (420 mg) were added to the resulting solution, followed by stirring at room temperature for 2.5 hours. The reaction mixture was distilled under reduced pressure. The residue was subjected to chromatography on a silica gel column (hexane:ethyl acetate=9:1), whereby the title compound (3.07 g) was obtained as pale yellow oil.
후처리
- distillationThe reaction mixture was distilled under reduced pressure
- customwas obtained as pale yellow oil
출처 및 근거
- ORD 기록
- ord-ad5fea9e0b5f4ceb8a3ddf1d9c72e567
- 출처 데이터셋
- uspto-grants-2004_06
- 특허 번호
- US06747023B1
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