4-Methylmorpholine → 4-Chloro-2-methoxybenzaldehyde

HRID 352835

반응식

HRID 352835 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][OH:9])=[C:4]([O:10][CH3:11])[CH:3]=1.CN1CCOCC1>C(Cl)Cl.[Ru]([O-])(=O)(=O)=O.C([N+](CCC)(CCC)CCC)CC>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[O:9])=[C:4]([O:10][CH3:11])[CH:3]=1

참가 물질

5

반응물 2

HCID 79724-MethylmorpholineHCID 35493934 Chloro-2-methoxybenzyl alcohol

생성물 1

HCID 138651154-Chloro-2-methoxybenzaldehyde

시약·촉매·용매 2

HCID 178419074HCID 178419074, 화합물촉매HCID 6344Dichloromethane용매

실험 절차

In methylene chloride (80 ml) was dissolved (4-chloro-2-methoxyphenyl)methanol (3.69 g). Under ice cooling, molecular sieve 4A (4.57 g), N-methylmorpholine (2.81 g) and tetra-n-propylammonium perruthenate (420 mg) were added to the resulting solution, followed by stirring at room temperature for 2.5 hours. The reaction mixture was distilled under reduced pressure. The residue was subjected to chromatography on a silica gel column (hexane:ethyl acetate=9:1), whereby the title compound (3.07 g) was obtained as pale yellow oil.

후처리

  1. distillationThe reaction mixture was distilled under reduced pressure
  2. customwas obtained as pale yellow oil

출처 및 근거

ORD 기록
ord-ad5fea9e0b5f4ceb8a3ddf1d9c72e567
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06747023B1

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