반응식
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([S:12]([N:15]1[CH2:20][CH2:19][N:18]([C:21]([C:23]3[S:24][C:25]4[CH2:26][NH:27][CH:28]([CH3:32])[CH2:29][C:30]=4[N:31]=3)=[O:22])[CH:17]([C:33]([O:35]CC)=[O:34])[CH2:16]1)(=[O:14])=[O:13])[CH:6]=[CH:5]2.C(O)C.[OH-].[Na+].O>O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([S:12]([N:15]1[CH2:20][CH2:19][N:18]([C:21]([C:23]3[S:24][C:25]4[CH2:26][NH:27][CH:28]([CH3:32])[CH2:29][C:30]=4[N:31]=3)=[O:22])[CH:17]([C:33]([OH:35])=[O:34])[CH2:16]1)(=[O:14])=[O:13])[CH:6]=[CH:5]2참가 물질
6
반응물 4
생성물 1
시약·촉매·용매 1
실험 절차
In tetrahydrofuran (10 ml), 4-[(6-chloronaphthalen-2-yl)sulfonyl]-2-(ethoxycarbonyl)-1-[(6-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]piperazine (2.08 g) was dissolved, followed by the addition of ethanol (20 ml) and a 1N aqueous solution (3.70 ml) of sodium hydroxide. The resulting mixture was stirred at room temperature for 1 hour. After concentration of the reaction mixture under reduced pressure, the residue was added with water (20 ml). The precipitate thus formed was collected by filtration, whereby the title compound (1.39 g) was obtained as a pale yellow foam.
후처리
- customThe precipitate thus formed
- filtrationwas collected by filtration, whereby the title compound (1.39 g)
- customwas obtained as a pale yellow foam
출처 및 근거
- ORD 기록
- ord-90f2c4195fba489180b31f4618eb5a99
- 출처 데이터셋
- uspto-grants-2004_06
- 특허 번호
- US06747023B1
연결된 노트
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