Ethanolamine → N-(2-Hydroxyethyl)pyrazine-2-carboxamide

HRID 35313

반응식

HRID 35313 반응식
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7]([O:9]C)=O.[NH2:11][CH2:12][CH2:13][OH:14]>C(OCC)(=O)C>[OH:14][CH2:13][CH2:12][NH:11][C:7]([C:2]1[CH:3]=[N:4][CH:5]=[CH:6][N:1]=1)=[O:9]

참가 물질

4

반응물 2

HCID 700EthanolamineHCID 72662Methyl pyrazinoate

생성물 1

HCID 14230272N-(2-Hydroxyethyl)pyrazine-2-carboxamide수율 80%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

A mixture of 55.2 parts of methyl 2-pyrazinecarboxylate, 48.9 parts of 2-aminoethanol and 360 parts of ethyl acetate was allowed to stand overnight at room temperature. The precipitated product was filtered off, washed with ethyl acetate and dried, yielding 54.5 parts (80%) of N-(2-hydroxyethyl)-2-pyrazinecarboxamide; mp. 125° C. (intermediate 22).

후처리

  1. filtrationThe precipitated product was filtered off
  2. washwashed with ethyl acetate
  3. customdried

출처 및 근거

ORD 기록
ord-5c89f624e3c24f21936bf0d2ca764d41
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04766125

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