Calcium hypochlorite → HCID 22708344, 화합물

HRID 353246

반응식

HRID 353246 반응식
[Cl:1][O-].[Ca+2].Cl[O-].[F:6][C:7]([F:21])([F:20])[O:8][C:9]1[CH:10]=[CH:11][CH:12]=[C:13]2[C:18]=1[O:17][CH2:16][CH2:15][C:14]2=[O:19]>O.C(O)(=O)C.C(#N)C.O>[Cl:1][C:11]1[CH:12]=[C:13]2[C:18](=[C:9]([O:8][C:7]([F:6])([F:20])[F:21])[CH:10]=1)[O:17][CH2:16][CH2:15][C:14]2=[O:19]

참가 물질

6

반응물 2

HCID 24504Calcium hypochloriteHCID 22708350HCID 22708350, 화합물

생성물 1

HCID 22708344HCID 22708344, 화합물수율 87%

시약·촉매·용매 3

HCID 962Water용매HCID 6342Acetonitrile용매HCID 21899381Acetic acid--water (1/1)용매

실험 절차

To a solution of calcium hypochlorite (15.4 g, 72.4 mmol) in water:acetic acid (65:5) was added a solution of 8-trifluoromethoxychroman-4-one (4.2 g, 18.1 mmol; from step (iv) above) in acetonitrile (20 mL), whereafter the reaction mixture was stirred overnight. The mixture was diluted with water and extracted with ether (3 times) and EtOAc (once). The combined organic layer was washed with water, dried (Na2SO4) and evaporated, yielding 4.2 g (87%) of the sub-tide compound.

후처리

  1. extractionextracted with ether (3 times) and EtOAc (once)
  2. washThe combined organic layer was washed with water
  3. dry with materialdried (Na2SO4)
  4. customevaporated

출처 및 근거

ORD 기록
ord-043020b1396d4c3b960816fe83620a9d
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06750243B1

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