Water → HCID 54262013, 화합물

반응식

Cl.[CH3:2][N:3]1[CH:7]=[C:6]([NH:8][C:9]([C:11]2[N:12]([CH3:28])[CH:13]=[C:14]([NH:16][C:17]([C:19]3[N:23]([CH3:24])[N:22]=[C:21]([N+:25]([O-:27])=[O:26])[CH:20]=3)=[O:18])[CH:15]=2)=[O:10])[CH:5]=[C:4]1[C:29]([NH:31][CH2:32][CH2:33][C:34]([NH2:36])=N)=[O:30].[OH2:37]>C(#N)C.[OH-].[Na+]>[CH3:2][N:3]1[CH:7]=[C:6]([NH:8][C:9]([C:11]2[N:12]([CH3:28])[CH:13]=[C:14]([NH:16][C:17]([C:19]3[N:23]([CH3:24])[N:22]=[C:21]([N+:25]([O-:27])=[O:26])[CH:20]=3)=[O:18])[CH:15]=2)=[O:10])[CH:5]=[C:4]1[C:29]([NH:31][CH2:32][CH2:33][C:34]([NH2:36])=[O:37])=[O:30]

참가 물질

반응 조건

온도: 60 °C

실험 절차

To a solution of 200 mg of 3-(1-methyl-4 (1-methyl-4-(1-methyl-3-nitropyrazole-5-carboxamido)pyrrole-2-carboxamido)pyrrole-2-carboxamido)propionamidine hydrochloride (prepared as described in WO 96/05196) in 10 ml of acetonitrile and 10 ml of water, 2 ml of NaOH 1N were added. The solution was heated at 60° C. for 4 hours then the solvent was evaporated in vacuo and the crude residue was purified by flash chromatography (methylene chloride/methanol: 10/1) affording 175 mg of 3-(1-methyl-4(1-methyl-4-(1-methyl-3-nitropyrazole-5-carboxamido)pyrrole-2-carboxamido)pyrrole-2-carboxamido)propionamide as a light yellow solid.