Hydroquinone → Bis(hydroxypropyl) fumarate

HRID 353498

반응식

HRID 353498 반응식
[C:1]([O:10][CH2:11][CH3:12])(=[O:9])/[CH:2]=[CH:3]/[C:4]([O:6][CH2:7][CH3:8])=[O:5].C(O)[CH:14]([OH:16])C.[C:18]1(C=CC(O)=CC=1)[OH:19]>[Cl-].[Cl-].[Zn+2].C(O)C>[C:4]([O:6][CH2:7][CH2:8][CH2:18][OH:19])(=[O:5])/[CH:3]=[CH:2]/[C:1]([O:10][CH2:11][CH2:12][CH2:14][OH:16])=[O:9]

참가 물질

6

반응물 3

HCID 785HydroquinoneHCID 1030Propylene GlycolHCID 638144Diethyl fumarate

생성물 1

HCID 86587300Bis(hydroxypropyl) fumarate

시약·촉매·용매 2

HCID 3007855Zincchloride촉매HCID 702Ethanol용매

실험 절차

Poly(propylene fumarate) was synthesized following a two step procedure [11]. First, 1 mole of diethyl fumarate (Acros Organics, Pittsburgh, Pa.) and 3 moles of 1,2 propanediol (Acros Organics) were reacted using 0.01 moles ZnCl2 (Fisher Chemicals, Fair Lawn, N.J.) as a catalyst and 0.002 moles hydroquinone (Acros Organics) as a radical inhibitor. The reaction was run under a nitrogen blanket, producing bis(hydroxypropyl) fumarate as the main product and ethanol as a byproduct. Second, the bis(hydroxypropyl) fumarate was transesterified, producing poly(propylene fumarate) and 1,2 propanediol as a byproduct.

출처 및 근거

ORD 기록
ord-ff7b432d5b0e4004ab6d24459485836b
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06753358B2

연결된 노트

불러오는 중…