Sodium borohydride → 4-Methyl-4-(4-pyridin-3-yl-imidazol-1-yl)-pentan-1-ol

HRID 353777노트

반응식

HRID 353777 반응식
C[O:2][C:3](=O)[CH2:4][CH2:5][C:6]([CH3:19])([N:8]1[CH:12]=[C:11]([C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)[N:10]=[CH:9]1)[CH3:7].[BH4-].[Na+]>C(O)C>[CH3:19][C:6]([N:8]1[CH:12]=[C:11]([C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)[N:10]=[CH:9]1)([CH3:7])[CH2:5][CH2:4][CH2:3][OH:2]

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 207376634-Methyl-4-(4-pyridin-3-yl-imidazol-1-yl)pentanoic acid methyl ester

생성물 1

HCID 235114074-Methyl-4-(4-pyridin-3-yl-imidazol-1-yl)-pentan-1-ol수율 68%

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
50 °C

실험 절차

To a solution of 4-Methyl-4-(4-pyridin-3-yl-imidazol-1-yl)pentanoic acid methyl ester (1 eq) in ethanol was added sodium borohydride (4 eq) at room temperature. The reaction mixture was heated in a 50° C. oil bath for 60 minutes and then quenched by addition of H2O. Once the reaction solvent was removed in vacuo, a solution of the residue in dichloromethane was washed with NaCl(sat), dried over sodium sulfate, filtered and concentrated to give 4-Methyl-4-(4-pyridin-3-yl-imidazol-1-yl)-pentan-1-ol (68%). MH+(246).

후처리

  1. customquenched by addition of H2O
  2. customOnce the reaction solvent was removed in vacuo
  3. washa solution of the residue in dichloromethane was washed with NaCl(sat)
  4. dry with materialdried over sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-da984e0f24ee446daf973c45296d46cb
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06756359B2

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