Pyrrolidine → 2-(Pyrrolidin-1-yl)-1H-benzo[d]imidazole

HRID 353814

반응식

HRID 353814 반응식
Cl[C:2]1[NH:6][C:5]2[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=2[N:3]=1.[NH:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1>C(O)C>[N:11]1([C:2]2[NH:6][C:5]3[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=3[N:3]=2)[CH2:15][CH2:14][CH2:13][CH2:12]1

참가 물질

4

반응물 2

HCID 31268PyrrolidineHCID 785722-Chlorobenzimidazole

생성물 1

HCID 69918962-(Pyrrolidin-1-yl)-1H-benzo[d]imidazole수율 39.7%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
165 °C

실험 절차

2-Chloro-1H-benzimidazole (10.0 g, 0.066 mol), pyrrolidine (18.5 g, 0.26 mol), and ethanol (100 mL) were combined. The resulting solution was heated at 160-170° C. for 6 hours and then the solvent was evaporated. The resulting residue was mixed with water. The mixture was made strongly acidic with hydrochloric acid and then made basic with ammonium hydroxide. The resulting solid was isolated by filtration, washed with water and then air dried to provide 11.8 g of crude product as a tan powder. This material was recrystallized from ethyl acetate/methanol to provide 4.9 g of 2-pyrrolidino-1H-benzimidazole. Analysis: Calculated for C11H13N3: % C, 70.56; % H, 7.00; % N, 22.44. Found: % C, 70.13; % H, 7.05; % N, 22.70.

후처리

  1. customthe solvent was evaporated
  2. additionThe resulting residue was mixed with water
  3. customThe resulting solid was isolated by filtration
  4. washwashed with water
  5. customair dried
  6. customto provide 11.8 g of crude product as a tan powder
  7. customThis material was recrystallized from ethyl acetate/methanol

출처 및 근거

ORD 기록
ord-72dc2ca90ac5467e9e4f90f2467f17ca
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06756382B2

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