Chlorosulfonic acid → 6-(N-Chloroacetylaminomethyl)-5-hydroxy-4-chlorosulfonylindane

HRID 35413

반응식

HRID 35413 반응식
[Cl:1][CH2:2][C:3]([NH:5][CH2:6][C:7]1[CH:15]=[C:14]2[C:10]([CH2:11][CH2:12][CH2:13]2)=[CH:9][C:8]=1[OH:16])=[O:4].[Cl:17][S:18](O)(=[O:20])=[O:19]>>[Cl:1][CH2:2][C:3]([NH:5][CH2:6][C:7]1[CH:15]=[C:14]2[C:10]([CH2:11][CH2:12][CH2:13]2)=[C:9]([S:18]([Cl:17])(=[O:20])=[O:19])[C:8]=1[OH:16])=[O:4]

참가 물질

3

반응물 2

HCID 24638Chlorosulfonic acidHCID 212969152-Chloro-N-[(6-hydroxy-2,3-dihydro-1H-inden-5-yl)methyl]acetamide

생성물 1

HCID 212969316-(N-Chloroacetylaminomethyl)-5-hydroxy-4-chlorosulfonylindane

실험 절차

70 g (0.29 mole) of 6-(N-chloroacetylaminomethyl)-5-hydroxyindane are dissolved in 150 ml of chlorosulfonic acid, and the mixture is stirred for approx. 30 minutes at room temperature. The mixture is poured into ice water and the product is filtered off with suction. The initially crystalline material becomes oily after a little time and is employed in the next stage in this form without further purification.

후처리

  1. filtrationthe product is filtered off with suction
  2. customis employed in the next stage in this form without further purification

출처 및 근거

ORD 기록
ord-602c8eb7a33141f29baf3356b4e49d0a
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04766241

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