3-Chloro-2-methylanisole → 3-Chloro-o-cresol

HRID 354261

반응식

HRID 354261 반응식
[Cl:1][C:2]1[C:3]([CH3:10])=[C:4]([O:8]C)[CH:5]=[CH:6][CH:7]=1>S(=O)(=O)(O)O>[Cl:1][C:2]1[C:3]([CH3:10])=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1

참가 물질

3

반응물 1

HCID 767493-Chloro-2-methylanisole

생성물 1

HCID 148563-Chloro-o-cresol

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

실험 절차

3.1 g (0.02 mol) of 3-chloro-2-methylanisole are heated in 20 ml of 50% sulphuric acid for 18 hours with reflux. After cooling, the reaction mixture is extracted three times with dichloromethane, dried over sodium sulphate and concentrated to dryness under reduced pressure. 3-Chloro-2-methylphenol is obtained as a solid (2.9 g, content by HPLC: 11.7%, 12% of theory).

후처리

  1. temperaturewith reflux
  2. temperatureAfter cooling
  3. extractionthe reaction mixture is extracted three times with dichloromethane
  4. dry with materialdried over sodium sulphate
  5. concentrationconcentrated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-4f149bc2b5f84728ba42e39fa0b4c854
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06756512B2

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