Methanol → Methyl 2-(3-chlorophenyl)acetate

HRID 354372노트

반응식

HRID 354372 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=[O:10])[CH:5]=[CH:6][CH:7]=1.[CH3:12]O.OS(O)(=O)=O>ClC(Cl)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([O:11][CH3:12])=[O:10])[CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 158793-Chlorophenylacetic acid

생성물 1

HCID 2733544Methyl 2-(3-chlorophenyl)acetate수율 107.8%

시약·촉매·용매 1

HCID 63651,1-Dichloroethane용매

반응 조건

온도
80 °C

실험 절차

To a stirred solution of 3-chlorophenylacetic acid (21.76 g, 127.6 mmol) in dichloroethane (100 ml) was added MeOH (15.6 ml, 383 mmol) and H2SO4 (1 ml) at room temperature. After 20 minutes stirring, the mixture was heated at 80° C. for 2 h. The reaction mixture was poured into ice water and extracted with CHCl3. The combined extracts were washed with aq NaHCO3 and brine. After dried over Na2SO4, the extract was concentrated in vacuo to give methyl 3-chlorophenylacetate (25.4 g, 100%) as a colorless oil. 1H-NMR (CDCl3) δ3.60 (s, 2H), 3.70 (s, 3H), 7.15-7.26 (m, 4H).

후처리

  1. extractionextracted with CHCl3
  2. washThe combined extracts were washed with aq NaHCO3 and brine
  3. dry with materialAfter dried over Na2SO4
  4. concentrationthe extract was concentrated in vacuo

출처 및 근거

ORD 기록
ord-0a2defb579d449558261c7a696e581b3
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06756378B2

반응 노트

불러오는 중…