Acetic Acid → methyl 4-[2-(N-benzyloxycarbonyl-N-methylamino)ethylamino]benzoate

HRID 354495노트

반응식

HRID 354495 반응식
[CH2:1]([O:8][C:9]([N:11]([CH2:13][CH:14]=O)[CH3:12])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:16][O:17][C:18](=[O:26])[C:19]1[CH:24]=[CH:23][C:22]([NH2:25])=[CH:21][CH:20]=1.CC(O)=O.[BH3-]C#N.[Na+]>C1(C)C=CC=CC=1>[CH2:1]([O:8][C:9]([N:11]([CH2:13][CH2:14][NH:25][C:22]1[CH:21]=[CH:20][C:19]([C:18]([O:17][CH3:16])=[O:26])=[CH:24][CH:23]=1)[CH3:12])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 12082Methyl 4-aminobenzoateHCID 5003444Sodium cyanoborohydrideHCID 12010768Benzyl N-methyl-N-(2-oxoethyl)carbamate

생성물 1

HCID 23511696methyl 4-[2-(N-benzyloxycarbonyl-N-methylamino)ethylamino]benzoate수율 334.5%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A stirred solution of N-benzyloxycarbonyl-N-methylaminoacetaldehyde (1.77 g, 1.1 mmol) in toluene (3 mL) was added methyl-4-aminobenzoate (1.29 g, 8.5 mmol), and the mixture was stirred for 1 hr at room temp. The reaction mixture was evaporated under a reduced pressure and the residue was dissolved into MeCN (15 mL). To the solution was added AcOH (2.44 mL, 43 mmol) and NaBH3CN (2.67 g, 43 mmol), and the resulting mixture was stirred for 15 hr at room temp. The reaction was quenched by the addition of sat. NaHCO3. The mixture was extracted with EtOAc, washed with brine, dried over MgSO4, and evaporated. The residue was chromatographed on silica-gel with n-hexane: EtOAc (7:3, v/v) as eluent to give 1.26 g (43%) methyl 4-[2-(N-benzyloxy carbonyl-N-methylamino)ethylamino]benzoate as a colorless oil. 1H-NMR (CDCl3, 400 MHz) δ2.96 (s, 3H), 3.32 (br m, 2H), 3.50-3.60 (m, 2H), 3.82 (s, 3H), 5.15 (each d, 2H, J=14.6 Hz), 6.35 and 6.58 (m, total 2H), 7.36 (s, 5H), 7.76 and 7.84 (m, total 2H); MS (FAB) m/z 342 (M++1).

후처리

  1. customThe reaction mixture was evaporated under a reduced pressure
  2. dissolutionthe residue was dissolved into MeCN (15 mL)
  3. stirringthe resulting mixture was stirred for 15 hr at room temp
  4. customThe reaction was quenched by the addition of sat. NaHCO3
  5. extractionThe mixture was extracted with EtOAc
  6. washwashed with brine
  7. dry with materialdried over MgSO4
  8. customevaporated
  9. customThe residue was chromatographed on silica-gel with n-hexane: EtOAc (7:3

출처 및 근거

ORD 기록
ord-de2aa24645be4fc6b8cef0088cb51523
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06756378B2

반응 노트

불러오는 중…