Phenolate Sodium → 4-Hydroxybenzoic Acid

HRID 354722

반응식

HRID 354722 반응식
[C:1]1([O-:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Na+].[C:9]([O-:18])(=[O:17])C1C(=CC=CC=1)O.[Na+]>>[CH:3]1[C:4]([C:9]([OH:18])=[O:17])=[CH:5][CH:6]=[C:1]([OH:7])[CH:2]=1

참가 물질

3

반응물 2

HCID 4445035Phenolate SodiumHCID 16760658Sodium Salicylate

생성물 1

HCID 1354-Hydroxybenzoic Acid

실험 절차

In contrast to published information, it has been found that the degree of conversion of sodium phenolate to sodium salicylate is practically independent of the reaction temperature. At 165° C. and at 200° C., 85-88% conversion is easily obtained, but by-product formation is reduced as the temperature is increased. For instance, reaction at 140°-150° C. gives about 9% non-salicylic acids mostly 4-HBA in the crude product mixture whereas reaction at 190°-195° C. (at 5 bar co-pressure) gives less than 0.5% non-salicylic acids in the reaction product mixture.

후처리

  1. customAt 165° C. and at 200° C., 85-88% conversion is easily obtained
  2. temperatureis increased
  3. customFor instance, reaction at 140°-150° C.

출처 및 근거

ORD 기록
ord-65514b3ffcfc48acbebe8fbcb4f6b5c5
출처 데이터셋
uspto-grants-1983_03
특허 번호
US04376867

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