Fluorobenzene → 4-(4-Phenoxypiperidinyl)-2-phenylquinazoline

HRID 354800노트

반응식

HRID 354800 반응식
[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]=[C:10]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[N:9]=2)[CH2:4][CH2:3]1.[H-].[Na+].F[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>CN(C)C=O>[O:1]([CH:2]1[CH2:7][CH2:6][N:5]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]=[C:10]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[N:9]=2)[CH2:4][CH2:3]1)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1

참가 물질

5

반응물 3

HCID 10008FluorobenzeneHCID 24758Sodium hydrideHCID 127960301-(2-Phenyl-4-quinazolinyl)-4-piperidinol

생성물 1

HCID 205064734-(4-Phenoxypiperidinyl)-2-phenylquinazoline

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Equimolar quantities of 4-(4-hydroxypiperidinyl-2-phenylquinazoline, sodium hydride, and fluorobenzene are heated in dimethylformamide to prepare the title compound.

출처 및 근거

ORD 기록
ord-f87f2cf901e847b9a89111e22ac49735
출처 데이터셋
uspto-grants-1983_03
특허 번호
US04377582

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