Formamide → 6-Nitroquinazolin-4-amine

HRID 354844노트

반응식

HRID 354844 반응식
[NH2:1][C:2]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][C:3]=1[C:4]#[N:5].C(=O)([O-])[O-].[K+].[K+].[CH:19]([NH2:21])=O.CN(C)C=O>O>[NH2:5][C:4]1[C:3]2[C:2](=[CH:9][CH:8]=[C:7]([N+:10]([O-:12])=[O:11])[CH:6]=2)[N:1]=[CH:19][N:21]=1

참가 물질

6

반응물 4

HCID 713FormamideHCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 285322-Amino-5-nitrobenzonitrile

생성물 1

HCID 130604546-Nitroquinazolin-4-amine

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
150 °C

실험 절차

A mixture of 2-amino-5-nitrobenzonitrile (48.9 g), anhydrous potassium carbonate (45.6 g), formamide (240 ml) and N,N-dimethylformamide (200 ml) was stirred for 50 minutes at 150° C. and then cooled to ambient temperature. To the resultant mixture was added a small volume of water with stirring. Precipitated crystals were separated by filtration, washed three times with water and dried under reduced pressure to give crystalline 4-amino-6-nitroquinazoline (50.1 g).

후처리

  1. temperaturecooled to ambient temperature
  2. stirringwith stirring
  3. customPrecipitated crystals
  4. customwere separated by filtration
  5. washwashed three times with water
  6. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-2514f699f75441d8b6f11f2a320c5ad7
출처 데이터셋
uspto-grants-1983_03
특허 번호
US04377580

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