Chloride → 17beta-Benzoyloxy-5alpha-androstan-4-one

HRID 354915노트

반응식

HRID 354915 반응식
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:10][C@H:11]1[CH2:16][CH2:15][C@H:14]2[C@H:17]3[C@H:27]([CH2:28][CH2:29][C@:12]12[CH3:13])[C@:25]1([CH3:26])[C@H:20]([C:21](=[O:30])[CH2:22][CH2:23][CH2:24]1)[CH2:19][CH2:18]3.[Cl-]>N1C=CC=CC=1>[C:1]([O:10][C@H:11]1[CH2:16][CH2:15][C@H:14]2[C@H:17]3[C@H:27]([CH2:28][CH2:29][C@:12]12[CH3:13])[C@:25]1([CH3:26])[C@H:20]([C:21](=[O:30])[CH2:22][CH2:23][CH2:24]1)[CH2:19][CH2:18]3)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 312ChlorideHCID 7412Benzoyl chlorideHCID 15341898HCID 15341898, 화합물

생성물 1

HCID 1534189917beta-Benzoyloxy-5alpha-androstan-4-one

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To 12 ml of dry pyridine and 6 ml of benzoyl chloride is added 2.0 g of the product of Step F to form a solution which is heated on a steam bath for 30 min. and then poured into 175 ml of ice water and stirred to decompose the excess chloride. The reaction mixture is filtered, washed with water, and pumped dry under high vacuum at 50° C. to yield 1.7 g of final product.

후처리

  1. customto form a solution which
  2. temperatureis heated on a steam bath for 30 min.
  3. filtrationThe reaction mixture is filtered
  4. washwashed with water
  5. custompumped dry under high vacuum at 50° C.

출처 및 근거

ORD 기록
ord-20eaecd6abc74531a2c2484020935134
출처 데이터셋
uspto-grants-1983_03
특허 번호
US04377584

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