Water → Sulbactam

HRID 354916

반응식

HRID 354916 반응식
[CH3:1][C:2]1([CH3:15])[S:6](=[O:8])(=[O:7])[CH:5]2[CH2:9][C:10](=[O:11])[N:4]2[CH:3]1[C:12]([O-:14])=[O:13].[Na+].O.C(=O)(O)[O-].[Na+].S([O-])([O-])(=O)=O.[Na+].[Na+]>S(=O)(=O)(O)[O-].C([N+](CCCC)(CCCC)CCCC)CCC.C(Cl)(Cl)Cl>[CH3:1][C:2]1([CH3:15])[S:6](=[O:7])(=[O:8])[C@@H:5]2[CH2:9][C:10](=[O:11])[N:4]2[C@H:3]1[C:12]([OH:14])=[O:13]

참가 물질

7

반응물 4

HCID 962WaterHCID 24436Sodium SulfateHCID 516892Sodium BicarbonateHCID 23691718Sodium penicillanate 1,1-dioxide

생성물 1

HCID 130313Sulbactam

시약·촉매·용매 2

HCID 94433Tetrabutylammonium hydrogen sulfate촉매HCID 6212Chloroform용매

실험 절차

To a stirred solution of 2.55 g. of sodium penicillanate 1,1-dioxide in 20 ml. of water was added 3.80 g. of tetrabutylammonium bisulfate. Stirring was continued for 5 minutes and then 20 ml. of chloroform was added. The pH was adjusted to 6.8 with saturated aqueous sodium bicarbonate and then the aqueous layer was saturated with sodium sulfate. The layers were separated and the aqueous layer was extracted with chloroform. The combined chloroform solutions were dried using sodium sulfate and then evaporated in vacuo to give the tetrabutylammonium salt of penicillanic acid 1,1-dioxide.

후처리

  1. customThe layers were separated
  2. extractionthe aqueous layer was extracted with chloroform
  3. dry with materialThe combined chloroform solutions were dried
  4. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-ac2e53e3cddb465cb06bb2f8c3814586
출처 데이터셋
uspto-grants-1983_03
특허 번호
US04377590

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