1-Bromo-3-chloropropane → 1-(3-chloropropyl)-2-phenyl-1H-benzimidazole

HRID 354928

반응식

HRID 354928 반응식
[C:1]1([C:7]2[NH:11][C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=3[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C[O-].[Na+].Br[CH2:20][CH2:21][CH2:22][Cl:23]>CC(O)C>[Cl:23][CH2:22][CH2:21][CH2:20][N:11]1[C:10]2[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=2[N:8]=[C:7]1[C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

5

반응물 3

HCID 80061-Bromo-3-chloropropaneHCID 128552-PhenylbenzimidazoleHCID 10942334Sodium Methoxide

생성물 1

HCID 205062561-(3-chloropropyl)-2-phenyl-1H-benzimidazole

시약·촉매·용매 1

HCID 3776Isopropanol용매

반응 조건

온도
50 °C

실험 절차

A mixture of 38.8 parts of 2-phenyl-1H-benzimidazole, 44 parts of a sodium methoxide solution 30% and 320 parts of 2-propanol is stirred and heated for 15 minutes at 50° C. After cooling, there are added 47.25 parts of 1-bromo-3-chloropropane. The whole is stirred and refluxed for 3 hours. The reaction mixture is evaporated. The residue is diluted with water and the product is extracted with methylbenzene. The extract is dried, filtered and evaporated, yielding 1-(3-chloropropyl)-2-phenyl-1H-benzimidazole as a residue.

후처리

  1. temperatureAfter cooling
  2. stirringThe whole is stirred
  3. temperaturerefluxed for 3 hours
  4. customThe reaction mixture is evaporated
  5. additionThe residue is diluted with water
  6. extractionthe product is extracted with methylbenzene
  7. customThe extract is dried
  8. filtrationfiltered
  9. customevaporated

출처 및 근거

ORD 기록
ord-839dba5ff7384a6fa41039c5aee44343
출처 데이터셋
uspto-grants-1983_03
특허 번호
US04377578

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