Isobutyric Acid → 5-Chloro-2,3-dimethylpentanoic acid

HRID 355355

반응식

HRID 355355 반응식
BrC[CH2:3][CH2:4][CH:5]([CH3:11])[CH:6]([CH3:10])[C:7]([OH:9])=[O:8].C(O)(=O)C(C)C.[Cl:18]CCCCl>>[Cl:18][CH2:3][CH2:4][CH:5]([CH3:11])[CH:6]([CH3:10])[C:7]([OH:9])=[O:8]

참가 물질

4

반응물 3

HCID 6590Isobutyric AcidHCID 88811,3-DichloropropaneHCID 189421366-Bromo-2,3-dimethylhexanoic acid

생성물 1

HCID 189421345-Chloro-2,3-dimethylpentanoic acid

실험 절차

The title compound was prepared as described for 6-bromo-2,3-dimethylhexanoic acid from isobutyric acid (9.67 g, 109.8 mmol), and 1,3-dichloropropane (37.2 g, 329.2 mmol). The product was purified by flash chromatography (CHCl3) to provide the acid (0.9 g, 5%) as a oil, HRMS (M+Li)+ calcd for C7H13O2ClLi 171.0764, found 171.0766.

후처리

  1. customThe product was purified by flash chromatography (CHCl3)

출처 및 근거

ORD 기록
ord-9dc23f2b8639435eb4cb47e15da30ebc
출처 데이터셋
uspto-grants-1998_11
특허 번호
US05830888

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