Piperidine → 1-(4-Fluorophenyl)piperidine

반응식

Cl[C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][CH:3]=1.[NH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1.CC(C)([O-])C.[K+].[Br-].[Li+]>C1(C)C=CC=CC=1>[F:8][C:5]1[CH:6]=[CH:7][C:2]([N:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)=[CH:3][CH:4]=1.[F:8][C:5]1[CH:4]=[C:3]([N:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)[CH:2]=[CH:7][CH:6]=1

참가 물질

반응물 4

HCID 8082Piperidine

HCID 9604Benzene, 1-chloro-4-fluoro-

HCID 82050Lithium Bromide

HCID 23665647Potassium tert-butoxide

생성물 2

HCID 108669271-(4-Fluorophenyl)piperidine

HCID 10921100HCID 10921100, 화합물

시약·촉매·용매 1

실험 절차

2.0 mmol of 4-chlorofluorobenzene, 2.4 mmol of piperidine, 2.8 mmol of potassium tert-butoxide, 0.4 mmol of lithium bromide, 1.0 mol-% (9.4 mg) of palladacycle (trans-di(μ-aceto)-bis[o[di-o-tolylphosphino)benzyl]dipalladium(II) in 10 ml of toluene are reacted according to the GWI to give 4-fluorophenylpiperidine and 3-fluorophenylpiperidine in the ratio 2:1 in 75% yield.

출처 및 근거

ORD 기록: ord-29dd7c87eeb74214955228b88959e0bd
출처 데이터셋: uspto-grants-1998_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05831128

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