Potassium Carbonate → 6-(3-Piperidinomethylphenoxy)hexanenitrile

HRID 35593

반응식

HRID 35593 반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][CH:14]=1)[CH2:5][N:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1.Br[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21]#[N:22].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[N:6]1([CH2:5][C:4]2[CH:3]=[C:2]([CH:14]=[CH:13][CH:12]=2)[O:1][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21]#[N:22])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 810936-BromohexanenitrileHCID 8269741-(3-Hydroxybenzyl)piperidine

생성물 1

HCID 212945996-(3-Piperidinomethylphenoxy)hexanenitrile

시약·촉매·용매 1

HCID 180Acetone용매

반응 조건

온도
100 °C

실험 절차

N-(3-Hydroxybenzyl)piperidine (9.55 g) was heated with 6-bromohexanenitrile (10.2 g) and potassium carbonate (13.8 g) under reflux in acetone (150 ml) for 66 hours. The reaction mixture was cooled and filtered. The solvent was removed by evaporation and the residue was heated with stirring at 100° C. for one hour to remove unreacted 6-bromohexanenitrile and to yield 6-(3-piperidinomethylphenoxy)hexanenitrile as an oil.

후처리

  1. temperatureThe reaction mixture was cooled
  2. filtrationfiltered
  3. customThe solvent was removed by evaporation
  4. temperaturethe residue was heated
  5. customto remove unreacted 6-bromohexanenitrile

출처 및 근거

ORD 기록
ord-7da3d269d1874f798df02cc7c96fa40f
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04767769

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