Acetic Acid → 2,8-Diacetylamino-1-tetralone
반응식
[C:1]([NH:4][C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:14]=1[C:13](=[O:15])[C:12](=[N:16]O)[CH2:11][CH2:10]2)(=[O:3])[CH3:2].[C:18](O)(=[O:20])[CH3:19]>C(OC(=O)C)(=O)C.[Zn]>[C:18]([NH:16][CH:12]1[CH2:11][CH2:10][C:9]2[C:14](=[C:5]([NH:4][C:1](=[O:3])[CH3:2])[CH:6]=[CH:7][CH:8]=2)[C:13]1=[O:15])(=[O:20])[CH3:19]참가 물질
5
실험 절차
1 gm of zinc powder was added to a solution of 300 mg of the compound prepared in (2) above dissolved in a mixed solvent of 10 ml of acetic acid and 10 ml of acetic anhydride, and the mixture was stirred for 40 minutes at room temperature. Insoluble substances were removed by filtration and filtrate was concentrated. The residue was recrystallized in ethyl acetate and hexane to obtain 263 mg of the title compound.
후처리
- customInsoluble substances were removed by filtration and filtrate
- concentrationwas concentrated
- customThe residue was recrystallized in ethyl acetate
출처 및 근거
- ORD 기록
- ord-4f6593ea681143ac8b6e501516b36baf
- 출처 데이터셋
- uspto-grants-1998_11
- 특허 번호
- US05834476
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