Dimethylformamide → 4-(3-Dimethylaminophenoxy)butyronitrile

HRID 35601

반응식

HRID 35601 반응식
[CH3:1][N:2]([CH3:10])[C:3]1[CH:4]=[C:5]([OH:9])[CH:6]=[CH:7][CH:8]=1.C(=O)([O-])[O-].[K+].[K+].CN(C)C=O.Br[CH2:23][CH2:24][CH2:25][C:26]#[N:27]>O>[CH3:1][N:2]([CH3:10])[C:3]1[CH:4]=[C:5]([CH:6]=[CH:7][CH:8]=1)[O:9][CH2:23][CH2:24][CH2:25][C:26]#[N:27]

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 74213-(Dimethylamino)phenolHCID 11430Potassium CarbonateHCID 214124-Bromobutyronitrile

생성물 1

HCID 212945174-(3-Dimethylaminophenoxy)butyronitrile

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A suspension of 3-dimethylaminophenol (5 g), potassium carbonate (10.05 g) and dimethylformamide (85 ml) was stirred at room temperature for 5 hours. 4-Bromobutyronitrile (7.3 ml) was added and the suspension stirred for 17 hours. The reaction mixture was poured into water and extracted with ethyl acetate. The extracts were washed with water, dried and the solvent removed to yield 4-(3-dimethylaminophenoxy)butyronitrile.

후처리

  1. stirringthe suspension stirred for 17 hours
  2. extractionextracted with ethyl acetate
  3. washThe extracts were washed with water
  4. customdried
  5. customthe solvent removed

출처 및 근거

ORD 기록
ord-7c7eb924af47428b8286be45c1256f2f
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04767769

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