Sodium cyanoborohydride → 6-Chloro-5-methylthioindoline

HRID 356030노트

반응식

HRID 356030 반응식
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[CH:7][NH:8]2)=[CH:4][C:3]=1[S:11][CH3:12].C([BH3-])#N.[Na+]>>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][NH:8]2)=[CH:4][C:3]=1[S:11][CH3:12]

참가 물질

3

반응물 2

HCID 5003444Sodium cyanoborohydrideHCID 105598586-Chloro-5-methylthioindole

생성물 1

HCID 105599346-Chloro-5-methylthioindoline수율 98.8%

실험 절차

6-Chloro-5-methylthioindole (D47) (0.72 g, 3.65 mmol) was treated with sodium cyanoborohydride as in the method of Description 10 to give the title compound (0.72 g, 98%) as a pale yellow oil.

출처 및 근거

ORD 기록
ord-c3f24d915a3d42d1b09b54ad2d686ba6
출처 데이터셋
uspto-grants-1998_11
특허 번호
US05834494

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