Methyl (4-nitrophenoxy)acetate → Methyl(4-aminophenoxy)acetate

HRID 356284

반응식

HRID 356284 반응식
[N+:1]([C:4]1[CH:15]=[CH:14][C:7]([O:8][CH2:9][C:10]([O:12][CH3:13])=[O:11])=[CH:6][CH:5]=1)([O-])=O>[Pd].CO>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([O:8][CH2:9][C:10]([O:12][CH3:13])=[O:11])=[CH:14][CH:15]=1

참가 물질

4

반응물 1

HCID 700522Methyl (4-nitrophenoxy)acetate

생성물 1

HCID 6422115Methyl(4-aminophenoxy)acetate수율 97.6%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A procedure similar to that described in Example 6 was repeated, except that 30.8 g of methyl 4-nitro-phenoxyacetate (prepared as described in Preparation 36), 5.0 g of 10% w/w palladium-on-charcoal and 500 ml of methanol were used, to give 25.8 g of the title compound having Rf=0.79 (on silica gel thin layer chromatography using ethyl acetate as the developing solvent).

출처 및 근거

ORD 기록
ord-d75c053e7dda43a784c033be9ddf82c9
출처 데이터셋
uspto-grants-1998_11
특허 번호
US05834501

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