Sodium Hydroxide → 2-Chloro-1,3-thiazole-4-carboxylic acid

HRID 356440노트

반응식

HRID 356440 반응식
[OH-].[Na+].C([O:5][C:6]([C:8]1[N:9]=[C:10]([Cl:13])[S:11][CH:12]=1)=[O:7])C>C(O)C>[Cl:13][C:10]1[S:11][CH:12]=[C:8]([C:6]([OH:7])=[O:5])[N:9]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 13106141Ethyl 2-chlorothiazole-4-carboxylate

생성물 1

HCID 218030262-Chloro-1,3-thiazole-4-carboxylic acid수율 61.1%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of NaOH (1.9 g, 47.5 mmol) and ethyl-2-chloro-4-thiazolecarboxylate (7.6 g, 40 mmol) in 100 mL absolute ethanol was stirred at RT for 4 h. After that, ethanol was removed in vacuo and the residue was dissolved in water. The aq layer was washed with ether and then acidified with conc HCl. The solid was filtered and air dried to give 4 g of 2-chloro-4-thiazolecarboxylic acid.

후처리

  1. customAfter that, ethanol was removed in vacuo
  2. dissolutionthe residue was dissolved in water
  3. washThe aq layer was washed with ether
  4. filtrationThe solid was filtered
  5. customair dried

출처 및 근거

ORD 기록
ord-a8762a94cad2465db75febb4a7a983fd
출처 데이터셋
uspto-grants-1998_11
특허 번호
US05834447

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