Neopentyl alcohol → 2,2-Dimethylpropyl chloro(oxo)acetate

반응식

[CH2:1]([OH:6])[C:2]([CH3:5])([CH3:4])[CH3:3].[C:7](Cl)(=[O:11])[C:8]([Cl:10])=[O:9]>>[C:8]([Cl:10])(=[O:9])[C:7]([O:6][CH2:1][C:2]([CH3:5])([CH3:4])[CH3:3])=[O:11]

참가 물질

반응물 2

HCID 6404Neopentyl alcohol

HCID 65578Oxalyl chloride2회

생성물 1

HCID 196123272,2-Dimethylpropyl chloro(oxo)acetate수율 92.7%

실험 절차

In this example the product was prepared in two synthetic steps. In the first step neopentyl alcohol was reacted with 50% molar excess of oxalyl chloride. Upon completion of the reaction the excess oxalyl chloride was stripped from the product at reduced pressure to produce neopentyl chlorooxalate having an assay of 100% and in a corrected yield of 92.7%. In the second step neopentyl chlorooxalate was reacted with 2,5-dimethyl-2,5-dihydroperoxyhexane, in the presence of pyridine, to yield the product as described below:

출처 및 근거

ORD 기록: ord-a5664ebc0dbb44fc96eb46f12b32568e
출처 데이터셋: uspto-grants-1998_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05837782

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