Methanol → Ibuprofen methyl ester

HRID 356841

반응식

[CH3:1][C@H:2]([C:13]([OH:15])=[O:14])[C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH:10]([CH3:12])[CH3:11])=[CH:5][CH:4]=1.S(=O)(=O)(O)O.[CH3:21]O>>[CH3:12][CH:10]([CH2:9][C:6]1[CH:7]=[CH:8][C:3]([CH:2]([C:13]([O:15][CH3:21])=[O:14])[CH3:1])=[CH:4][CH:5]=1)[CH3:11]

참가 물질

반응물 3

HCID 887Methanol

HCID 1118Sulfuric Acid

HCID 39912Dexibuprofen

생성물 1

HCID 109101Ibuprofen methyl ester

실험 절차

S-(+)-ibuprofen (5.0 g; 0.024 mole) was shed into methanol (35 ml), concentrated sulfuric acid (1 ml) was added and the reaction mixture was heated for 3 hours at the reflux temperature of the reaction mixture. Then it was evaporated in vacuo at the temperature of 30° C. to dryness. S-(+)-ibuprofen methyl ester (5.1 g) was obtained.

후처리

additionwas added
temperaturethe reaction mixture was heated for 3 hours at the reflux temperature of the reaction mixture
customThen it was evaporated in vacuo at the temperature of 30° C. to dryness

출처 및 근거

ORD 기록: ord-df4c121a7edc488eacf23da102b372c5
출처 데이터셋: uspto-grants-1998_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05840714

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