Hydrochloric Acid → Methyl 12-aminododecanoate

HRID 356883

반응식

HRID 356883 반응식
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14].Cl.[CH3:17]O>>[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([O:15][CH3:17])=[O:14]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 6966112-Aminododecanoic Acid

생성물 1

HCID 3665980Methyl 12-aminododecanoate수율 98%

실험 절차

To a suspension of 12-aminododecanoic acid (5.00 g, 23.3 mmol) in anhydrous MeOH (90 mL) was introduced hydrogen chloride gas for 25 minutes, during which time the suspension became clear. The solution was then stirred at room temperature for 3 hours and the solvent was removed in vacuo. The white solid residue was dissolved in H2O. Solid NaHCO3 was added to neutralize the solution to pH 8-9. The white precipitates thus formed were collected by vacuum filtration (5.20 g) (Yield: 98%).

후처리

  1. customthe solvent was removed in vacuo
  2. dissolutionThe white solid residue was dissolved in H2O
  3. additionSolid NaHCO3 was added
  4. customThe white precipitates thus
  5. customformed
  6. filtrationwere collected by vacuum filtration (5.20 g) (Yield: 98%)

출처 및 근거

ORD 기록
ord-556f974df338495bab3fc6a50f4c8596
출처 데이터셋
uspto-grants-1998_11
특허 번호
US05840733

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