Bromoacetone → 5-Chloro-2-methylimidazo[1,2-a]pyridine hydrobromide

HRID 357018

반응식

HRID 357018 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[N:3]=1.[Br:9][CH2:10][C:11](=O)[CH3:12]>C(O)C>[BrH:9].[Cl:8][C:4]1[N:3]2[CH:10]=[C:11]([CH3:12])[N:1]=[C:2]2[CH:7]=[CH:6][CH:5]=1

참가 물질

4

반응물 2

HCID 11715BromoacetoneHCID 2062462-Amino-6-chloropyridine

생성물 1

HCID 189367145-Chloro-2-methylimidazo[1,2-a]pyridine hydrobromide

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 19.28 g (150 mmol) of 2-amino-6-chloropyridine in 150 ml of ethanol, 25 g (180 mmol) of bromoacetone was added at room temperature, followed by refluxing for 64 hours. After the reaction mixture was cooled, the solvent was distilled off. The residue was purified by recrystallization (solvent: ethanol-ethyl acetate) to yield 20.22 g (54.5%, light brown crystal) of the desired product.

후처리

  1. temperatureby refluxing for 64 hours
  2. temperatureAfter the reaction mixture was cooled
  3. distillationthe solvent was distilled off
  4. customThe residue was purified by recrystallization (solvent: ethanol-ethyl acetate)

출처 및 근거

ORD 기록
ord-4df35b6cb8814ed7a93fd8fdc541f9cf
출처 데이터셋
uspto-grants-1998_11
특허 번호
US05840732

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