Hydrochloric Acid → 5-Propylidene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione hydrochloride

HRID 357048노트

반응식

HRID 357048 반응식
[CH:1](=[C:4]1[S:8][C:7](=[O:9])[N:6]([CH2:10][CH2:11][CH2:12][CH2:13][S:14][C:15]2[N:20]3[CH:21]=[CH:22][N:23]=[C:19]3[CH:18]=[CH:17][CH:16]=2)[C:5]1=[O:24])[CH2:2][CH3:3].[ClH:25]>CO>[ClH:25].[CH:1](=[C:4]1[S:8][C:7](=[O:9])[N:6]([CH2:10][CH2:11][CH2:12][CH2:13][S:14][C:15]2[N:20]3[CH:21]=[CH:22][N:23]=[C:19]3[CH:18]=[CH:17][CH:16]=2)[C:5]1=[O:24])[CH2:2][CH3:3]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 572936285-Propylidene-3-(4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione

생성물 1

HCID 867533435-Propylidene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione hydrochloride

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 1.37 g (3.79 mmol) of 5-propylidene-3-(4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione in 50 ml of methanol, 0.35 ml of concentrated hydrochloric acid was added. After the solvent was distilled off, the residue was washed with diethyl ether to yield 1.66 g (100%, yellow oily substance) of the desired product.

후처리

  1. distillationAfter the solvent was distilled off
  2. washthe residue was washed with diethyl ether

출처 및 근거

ORD 기록
ord-d7fbf8f54d604229b9caa460a7e9750e
출처 데이터셋
uspto-grants-1998_11
특허 번호
US05840732

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