Hydrochloric Acid → 5-(Dimethylamino)methylene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione dihydrochloride

HRID 357090노트

반응식

HRID 357090 반응식
[CH3:1][N:2]([CH:4]=[C:5]1[S:9][C:8](=[O:10])[N:7]([CH2:11][CH2:12][CH2:13][CH2:14][S:15][C:16]2[N:21]3[CH:22]=[CH:23][N:24]=[C:20]3[CH:19]=[CH:18][CH:17]=2)[C:6]1=[O:25])[CH3:3].[ClH:26]>CO>[ClH:26].[ClH:26].[CH3:1][N:2]([CH:4]=[C:5]1[S:9][C:8](=[O:10])[N:7]([CH2:11][CH2:12][CH2:13][CH2:14][S:15][C:16]2[N:21]3[CH:22]=[CH:23][N:24]=[C:20]3[CH:19]=[CH:18][CH:17]=2)[C:6]1=[O:25])[CH3:3]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 537972345-(Dimethylamino)methylene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione

생성물 1

HCID 867533465-(Dimethylamino)methylene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione dihydrochloride

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 310 mg (0.823 mmol) of 5-(dimethylamino)methylene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione in 10 ml of methanol, concentrated hydrochloric acid was added. After the solvent was distilled off, the residue was washed with diethyl ether to yield 311 mg (84.1%, white powder) of the desired product.

후처리

  1. distillationAfter the solvent was distilled off
  2. washthe residue was washed with diethyl ether

출처 및 근거

ORD 기록
ord-6f729da9927e490292e5feca1d7854ae
출처 데이터셋
uspto-grants-1998_11
특허 번호
US05840732

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