Methyl 6-aminohexanoate → Caprolactam acetylene

HRID 35727

반응식

HRID 35727 반응식
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([O:9]C)=O>C1(C)C=C(C)C=C(C)C=1>[C:7]1(=[O:9])[NH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1.[CH:2]#[CH:3]

참가 물질

3

반응물 1

HCID 1810164Methyl 6-aminohexanoate

생성물 1

HCID 86742408Caprolactam acetylene수율 260.4%

시약·촉매·용매 1

HCID 7947Mesitylene용매

반응 조건

온도
140 °C

실험 절차

A solution of 37.1 g (0.256 mol) of methyl 6-aminocaproate in 723 g of mesitylene is stirred under reflux at 140° C./500 bar for 12 h. Evaporating off the mesitylene under reduced pressure leaves 46.4 g of a caprolactam-acetylene mixture which, according to HPLC, contains 58.2% of caprolactam, which corresponds to 27.0 g (0.239 mol) and a yield of 93.4%.

후처리

  1. customEvaporating off the mesitylene under reduced pressure

출처 및 근거

ORD 기록
ord-955be329f2be48739f9d648bd81f7872
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04767857

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