Hexane → 2-Amino-3-hydroxybenzonitrile

HRID 357292

반응식

HRID 357292 반응식
[N+:1]([C:4]1[C:11]([OH:12])=[CH:10][CH:9]=[CH:8][C:5]=1[C:6]#[N:7])([O-])=O.[H][H].CCCCCC.C(OCC)(=O)C>[Pd].C(O)C>[NH2:1][C:4]1[C:11]([OH:12])=[CH:10][CH:9]=[CH:8][C:5]=1[C:6]#[N:7]

참가 물질

7

반응물 4

HCID 8058HexaneHCID 8857Ethyl AcetateHCID 138624233-Hydroxy-2-nitrobenzonitrileHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 159063362-Amino-3-hydroxybenzonitrile

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A parr bottle was charged with palladium on activated carbon (5%, 0.196g). A solution of 2-nitro-3-hydroxybenzonitrile (1.31 g, 0.008 mol) in 40 ml of ethanol was added. The reaction mixture was placed under 25 psi of hydrogen gas and shaken for 1 hour. TLC (1:1 hexane:ethyl acetate) shows that no starting material remained. The mixture was filtered through Celite® and evaporated to yield 2-amino-3-hydroxybenzonitrile, 1.01 g (0.0075 mol, 94%).

후처리

  1. filtrationThe mixture was filtered through Celite®
  2. customevaporated

출처 및 근거

ORD 기록
ord-59f4430508a249a3b05078ccf53bc50f
출처 데이터셋
uspto-grants-1998_11
특허 번호
US05840764

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