Methanol → 1-Methyl-3,5-diphenylpyrazole

HRID 357531

반응식

HRID 357531 반응식
[C:1]1([C:7]2[CH:11]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[NH:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(OC)(O[CH3:22])(=O)=O.CO>>[CH3:22][N:8]1[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[CH:11][C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[N:9]1

참가 물질

4

반응물 3

HCID 887MethanolHCID 6497Dimethyl SulfateHCID 708401H-Pyrazole, 3,5-diphenyl-

생성물 1

HCID 1405171-Methyl-3,5-diphenylpyrazole수율 975.6%

반응 조건

온도
200 °C

실험 절차

As in Example 2, a melt consisting of 10 g (0.0455 mol) of 3,5-diphenylpyrazole and 0.057 g (0.00455 mol) of dimethyl sulfate was prepared at 200° C. Over the course of 5 hours, 435 g (13.6 mol) of methanol were vaporized at 155° C. and passed through the melt which was maintained at 200° C. 10.4 g (96.9%) of 1-methyl-3,5-diphenylpyrazole were obtained, boiling point 190° C./3 mbar, with a content of 99.2% (GC).

후처리

  1. customwas prepared at 200° C
  2. customwere vaporized at 155° C.

출처 및 근거

ORD 기록
ord-18b6bab8692a46d8a76e110c784769e9
출처 데이터셋
uspto-grants-1998_11
특허 번호
US05840913

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