Benzene → 2-Methylindanone
반응식
[Al+3].[Cl-].[Cl-].[Cl-].[CH:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.Br[C:12]([CH3:17])([CH3:16])[C:13](Br)=[O:14]>C(Cl)Cl>[CH3:16][CH:12]1[CH2:17][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:13]1=[O:14]참가 물질
5
실험 절차
17.3 g (125 mmol) of AlCl3 were added to a solution of 3.91 g (50 mmol) of benzene in 30 ml of analytical grade methylene chloride, while cooling with ice. 11.9 g (52 mmol) of 2-bromoisobutyryl bromide were then added, and stirring was continued at 0° C. for 1 hour and at room temperature for 2 hours. The mixture was heated under reflux for a further 15 hours and then worked up analogously to Example A. The crude product was chromatographed on 100 g of silica gel (hexane/methylene chloride 1:1). The yield was 5.1 g (70%).
후처리
- temperaturewhile cooling with ice
- temperatureThe mixture was heated
- temperatureunder reflux for a further 15 hours
- customThe crude product was chromatographed on 100 g of silica gel (hexane/methylene chloride 1:1)
출처 및 근거
- ORD 기록
- ord-f425ba351e92487292b7828877e57bd6
- 출처 데이터셋
- uspto-grants-1998_11
- 특허 번호
- US05840948
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