Methyl 3-bromothiophene-2-carboxylate → 3-Bromothiophene-2-carboxylic acid

HRID 357739

반응식

HRID 357739 반응식
C[O:2][C:3]([C:5]1[S:6][CH:7]=[CH:8][C:9]=1[Br:10])=[O:4]>CO.O1CCCC1.[OH-].[Na+]>[Br:10][C:9]1[CH:8]=[CH:7][S:6][C:5]=1[C:3]([OH:4])=[O:2]

참가 물질

5

반응물 1

HCID 2740074Methyl 3-bromothiophene-2-carboxylate

생성물 1

HCID 27396883-Bromothiophene-2-carboxylic acid수율 97.3%

시약·촉매·용매 3

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매HCID 14798Sodium Hydroxide용매

실험 절차

3-Bromo-2-thiophenecarboxylic acid methyl ester (7.74 g) was dissolved in a mixture of methanol (35 ml) and tetrahydrofuran (35 ml), and 1N aqueous sodium hydroxide (53 ml) was added. The mixture was stirred at room temperature for 2 hours and washed with diethyl ether. The aqueous layer was acidified with 1N hydrochloric acid and extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give 3-bromo-2-thiophenecarboxylic acid (7.05 g) as crystals.

후처리

  1. additionwas added
  2. washwashed with diethyl ether
  3. extractionextracted with ethyl acetate
  4. dry with materialThe extract was dried over anhydrous magnesium sulfate
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-2e768a02cf3442ff911f2d68e5377a5c
출처 데이터셋
uspto-grants-1998_11
특허 번호
US05840917

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