Water → Methyl 3-acetylthiophene-2-carboxylate

HRID 357756노트

반응식

HRID 357756 반응식
[C:1]([C:4]1[CH:8]=[CH:7][S:6][C:5]=1[C:9]([OH:11])=[O:10])(=[O:3])[CH3:2].IC.[C:14](=O)([O-])[O-].[K+].[K+].O>CN(C)C=O>[CH3:14][O:10][C:9]([C:5]1[S:6][CH:7]=[CH:8][C:4]=1[C:1](=[O:3])[CH3:2])=[O:11]

참가 물질

6

반응물 4

HCID 962WaterHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 8189273-Acetylthiophene-2-carboxylic acid

생성물 1

HCID 13156393Methyl 3-acetylthiophene-2-carboxylate수율 94.5%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

3-Acetyl-2-thiophenecarboxylic acid (3.0 g) was dissolved in N,N-dimethylformamide (50 ml), and iodomethane (4.0 ml) and potassium carbonate (6.0 g) were added. The mixture was stirred at room temperature for 3 hours, poured into water and extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give 3-acetyl-2-thiophenecarboxylic acid methyl ester (3.07 g) as crystals.

후처리

  1. extractionextracted with ethyl acetate
  2. dry with materialThe extract was dried over anhydrous magnesium sulfate
  3. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-398ade673da34c7fb5ce5c4962a77173
출처 데이터셋
uspto-grants-1998_11
특허 번호
US05840917

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