Sodium Hydroxide → 2-Methyl-3-furoic acid

HRID 357782

반응식

HRID 357782 반응식
C([O:3][C:4]([C:6]1[CH:10]=[CH:9][O:8][C:7]=1[CH3:11])=[O:5])C.[OH-].[Na+]>C(O)C>[CH3:11][C:7]1[O:8][CH:9]=[CH:10][C:6]=1[C:4]([OH:5])=[O:3]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 261900Ethyl 2-Methyl-3-furoate

생성물 1

HCID 2447562-Methyl-3-furoic acid수율 67.2%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2-Methyl-3-furancarboxylic acid ethyl ester (10 g) was dissolved in ethanol (70 ml), and 1N aqueous sodium hydroxide (78 ml) was added. The mixture was stirred at room temperature and concentrated under reduced pressure. The residue was dissolved in water and washed with diethyl ether. The aqueous layer was acidified with 1N hydrochloric acid and extracted with ethyl acetate. The extract was washed with water and saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. Precipitated crystals were collected by filtration to give 2-methyl-3-furancarboxylic acid (5.5 g) as crystals.

후처리

  1. concentrationconcentrated under reduced pressure
  2. dissolutionThe residue was dissolved in water
  3. washwashed with diethyl ether
  4. extractionextracted with ethyl acetate
  5. washThe extract was washed with water and saturated aqueous sodium chloride
  6. dry with materialdried over anhydrous magnesium sulfate
  7. concentrationconcentrated under reduced pressure
  8. customPrecipitated crystals
  9. filtrationwere collected by filtration

출처 및 근거

ORD 기록
ord-b933f011bb044043b97cfc5f3657c2dd
출처 데이터셋
uspto-grants-1998_11
특허 번호
US05840917

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