Water → Ethyl 4,5-dihydroimidazo[1,2-a]quinoxaline-2-carboxylate

HRID 358024노트

반응식

HRID 358024 반응식
Br.[CH:2]1[N:6]2[C:7]3[C:12]([N:13]=[CH:14][C:5]2=[N:4][C:3]=1[C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:11][CH:10]=[CH:9][CH:8]=3.[BH4-].[Na+].O>C(O)C>[CH:2]1[N:6]2[C:7]3[C:12]([NH:13][CH2:14][C:5]2=[N:4][C:3]=1[C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:11][CH:10]=[CH:9][CH:8]=3

참가 물질

5

반응물 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 20450288HCID 20450288, 화합물

생성물 1

HCID 13228326Ethyl 4,5-dihydroimidazo[1,2-a]quinoxaline-2-carboxylate수율 99.3%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a stirred solution of 1.6 g of ethyl imidazo[1,2-a]quinoxaline-2-carboxylate hydrobromide (British patent application Ser. No. 79-26597, in 50 ml of ethanol was added portionwise 0.5 g of sodium borohydride and at the completion of the reaction (tlc), the mixture was poured into 250 ml of water. The mixture was extracted with ethyl acetate and the organic layer was washed with water, dried and evaporated to dryness to obtain 1.2 g (97% yield) of ethyl 4,5-dihydroimidazo[1,2-a]quinoxaline-2-carboxylate melting at 206°-8° C.

후처리

  1. customat the completion of the reaction (tlc)
  2. extractionThe mixture was extracted with ethyl acetate
  3. washthe organic layer was washed with water
  4. customdried
  5. customevaporated to dryness

출처 및 근거

ORD 기록
ord-2947693e804a48768ca870206a4868c0
출처 데이터셋
uspto-grants-1984_08
특허 번호
US04464373

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