Hydrazine hydrate (1:1) → HCID 20450022, 화합물
반응식
O.[NH2:2][NH2:3].[Cl:4][C:5]1[CH:6]=[CH:7][C:8]2[NH:15][C:14](=S)[CH2:13][CH2:12][S:11](=[O:18])(=[O:17])[CH:10]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[F:25])[C:9]=2[CH:26]=1>O1CCCC1>[Cl:4][C:5]1[CH:6]=[CH:7][C:8]2[N:15]=[C:14]([NH:2][NH2:3])[CH2:13][CH2:12][S:11](=[O:18])(=[O:17])[CH:10]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[F:25])[C:9]=2[CH:26]=1참가 물질
4
실험 절차
A solution of 0.9 ml of hydrazine hydrate in 134 ml of tetrahydrofuran is treated with 6.2 g of 8-chloro-6-(2-fluorophenyl)-1,3,4,6-tetrahydro-2-thiono-2H-5,1-benzothiazocine 5,5-dioxide. The solution is stirred at room temperature under a stream of argon for 1.25 hours and then evaporated in vacuo. The residue is crystallized from diisopropyl ether, there being obtained 8-chloro-6-(2-fluorophenyl)-2-hydrazino-3,6-dihydro-4H-5,1-benzothiazocine 5,5-dioxide of melting point 159°.