Hydrazine hydrate (1:1) → HCID 20449960, 화합물

HRID 358069노트

반응식

HRID 358069 반응식
O.[NH2:2][NH2:3].[Cl:4][C:5]1[CH:6]=[CH:7][C:8]2[NH:14][C:13](=S)[CH2:12][CH2:11][CH:10]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[F:22])[C:9]=2[CH:23]=1>O1CCCC1>[Cl:4][C:5]1[CH:6]=[CH:7][C:8]2[NH:14][CH:13]([NH:2][NH2:3])[CH2:12][CH2:11][CH:10]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[F:22])[C:9]=2[CH:23]=1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 20450012HCID 20450012, 화합물

생성물 1

HCID 20449960HCID 20449960, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 17.5 ml of hydrazine hydrate in 1.75 l of tetrahydrofuran is treated with 22 g of 7-chloro-5-(2-fluorophenyl)-1,3,4,5-tetrahydro-2H-1-benzazepine-2-thione. The solution is stirred under a stream of argon for 2 hours and then evaporated at 40° in vacuo. The residue is crystallized from ether and there is obtained 7-chloro-5-(2-fluorophenyl)-2-hydrazino-4,5-dihydro-2H-1-benzazepine of melting point 213°-215°.

후처리

  1. customevaporated at 40° in vacuo
  2. customThe residue is crystallized from ether

출처 및 근거

ORD 기록
ord-d4d528c3364f41c2b739c5a22cb9bdf5
출처 데이터셋
uspto-grants-1984_08
특허 번호
US04464300

반응 노트

불러오는 중…