Ethyl Glycolate → Ethoxycarbonylmethyl 3-phenylpropanoate

HRID 358103

반응식

HRID 358103 반응식
[C:1](Cl)(=[O:10])[CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[C:12]([O:16][CH2:17][CH3:18])(=[O:15])[CH2:13][OH:14]>N1C=CC=CC=1>[C:1]([O:14][CH2:13][C:12]([O:16][CH2:17][CH3:18])=[O:15])(=[O:10])[CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

참가 물질

4

반응물 2

HCID 12184Ethyl GlycolateHCID 64801Benzenepropanoyl chloride

생성물 1

HCID 321703Ethoxycarbonylmethyl 3-phenylpropanoate

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

33.7 g (0.2 mole) of hydrocinnamoyl chloride was added to a stirred solution of 18 g (0.2 mole) of ethyl glycolate in 20 ml of pyridine. The precipitated pyridine hydrochloride was filtered, washed with benzene, and discarded. The benzene solution of carboethoxymethyl hydrocinnamate was water washed, dried over sodium sulfate, and the solvent stripped off using a rotary evaporator. The yield of product was essentially quantitative. Its structure was established by infrared and nuclear magnetic resonance spectroscopy. It had n30D 1.4900 and d304 1.0919.

후처리

  1. filtrationThe precipitated pyridine hydrochloride was filtered
  2. washwashed with benzene
  3. washwashed
  4. dry with materialdried over sodium sulfate
  5. customa rotary evaporator

출처 및 근거

ORD 기록
ord-a380bc8c55ea4569a6187fa61adaa645
출처 데이터셋
uspto-grants-1984_08
특허 번호
US04464392

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