Sodium Hydroxide → HCID 178484896, 화합물

HRID 358257노트

반응식

HRID 358257 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[CH:10][NH:11][CH:12]=2)=[CH:4][CH:3]=1.Cl.[CH3:14][N:15]=[CH:16]OCC.[OH-].[Na+]>C(O)C>[CH3:14][NH:15][CH:16]=[N:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:9]=[CH:10][NH:11][CH:12]=2)=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 12210271ethyl N-methyl-formimidate hydrochlorideHCID 178507418HCID 178507418, 화합물

생성물 1

HCID 178484896HCID 178484896, 화합물수율 34.8%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A suspension of 0.8 gm of 4-(4-aminophenyl)-1-H-imidazole and 1.86 gm of ethyl N-methyl-formimidate hydrochloride [F. H. Suydam et al., J. Org. Chem. 34, 292 (1969)] in 20 ml of anhydrous ethanol was stirred at room temperature for two days. The clear solution was evaporated to dryness, and the oily residue was dissolved in water. The solution so obtained was adjusted to pH 10 with 10% NaOH. The product which separated was extracted with ethyl acetate, the organic solution was evaporated to dryness, and the product obtained was purified through its hydorchloride salt to give 0.35 gm of the desired compound as crystalline solid.

후처리

  1. customThe clear solution was evaporated to dryness
  2. dissolutionthe oily residue was dissolved in water
  3. customThe solution so obtained
  4. customThe product which separated
  5. extractionwas extracted with ethyl acetate
  6. customthe organic solution was evaporated to dryness
  7. customthe product obtained
  8. customwas purified through its hydorchloride salt

출처 및 근거

ORD 기록
ord-d3b976f6f6d8451c91d2eac5a94e0ee4
출처 데이터셋
uspto-grants-1984_08
특허 번호
US04465841

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