2-Hydroxy-4-methoxybenzophenone → {4-Methoxy-2-[(prop-2-en-1-yl)oxy]phenyl}(phenyl)methanone

HRID 358382

반응식

HRID 358382 반응식
[OH:1][C:2]1[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[CH:12][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].[OH-].[K+].[CH2:20](Cl)[CH:21]=[CH2:22].[I-].[K+]>O1CCCC1>[CH2:22]([O:1][C:2]1[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[CH:12][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5])[CH:21]=[CH2:20]

참가 물질

6

반응물 4

HCID 46322-Hydroxy-4-methoxybenzophenoneHCID 4875Potassium IodideHCID 7850Allyl chlorideHCID 14797Potassium Hydroxide

생성물 1

HCID 14227056{4-Methoxy-2-[(prop-2-en-1-yl)oxy]phenyl}(phenyl)methanone

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

2-Hydroxy-4-methoxybenzophenone (114 parts) was dissolved in tetrahydrofuran (100 parts). Potassium hydroxide (30.9 parts) was added. By heating and stirring, complete dissolution was achieved. Allyl chloride (46.4 parts) and potassium iodide (4.2 parts) were added to this solution, which was then heated and refluxed for 8 hours. After cooling, it was washed with water and the solvent was removed by distillation. A crude product of the desired 2-allyloxy-4-methoxybenzophenone was obtained. It was recrystallized in n-hexane to obtain 125 parts of 2-allyloxy-4-methoxybenzophenone (melting point 40° C.) at 93% yield.

후처리

  1. temperatureBy heating
  2. dissolutioncomplete dissolution
  3. temperaturewas then heated
  4. temperaturerefluxed for 8 hours
  5. temperatureAfter cooling
  6. washit was washed with water
  7. customthe solvent was removed by distillation

출처 및 근거

ORD 기록
ord-b194dbbb179640d88942b8ef085f31a9
출처 데이터셋
uspto-grants-1984_08
특허 번호
US04467082

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