2-Butenoic acid, 3-amino-, ethyl ester → Ethyl 2-methyl-4-phenyl-1,4-dihydropyridine-3-carboxylate

HRID 358588

반응식

HRID 358588 반응식
[C:1]1(/[CH:7]=[CH:8]/[CH:9]=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:11][C:12]([CH3:19])=[CH:13][C:14]([O:16][CH2:17][CH3:18])=[O:15]>C(O)C.N1CCCCC1>[CH3:19][C:12]1[NH:11][CH:9]=[CH:8][CH:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[C:13]=1[C:14]([O:16][CH2:17][CH3:18])=[O:15]

참가 물질

5

반응물 2

HCID 953082-Butenoic acid, 3-amino-, ethyl esterHCID 637511Cinnamaldehyde

생성물 1

HCID 14652661Ethyl 2-methyl-4-phenyl-1,4-dihydropyridine-3-carboxylate수율 72.3%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 8082Piperidine용매

실험 절차

(E)-3-Phenyl-2-propenal (13.8 ml, 0.11 mol) and ethyl 3-amino-2-butenoate (12.9 g, 0.1 mol) were dissolved in 150 ml of absolute ethanol containing 0.5 ml of piperidine. The mixture was heated under reflux for 18 hours followed by removal of the solvent under vacuum to yield 17.6 g of ethyl 1,4-dihydro-2-methyl-4-phenyl-3-pyridinecarboxylate as a brown viscous oil.

후처리

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 18 hours
  3. customfollowed by removal of the solvent under vacuum

출처 및 근거

ORD 기록
ord-42e9defa45784b289909b967b73d63bc
출처 데이터셋
uspto-grants-1991_03
특허 번호
US04997837

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