Methyl 7-phthalimidohept-5-ynoate → 7-Phthalimidohept-5-ynoic Acid

HRID 358619노트

반응식

HRID 358619 반응식
[C:1]1(=[O:21])[N:5]([CH2:6][C:7]#[C:8][CH2:9][CH2:10][CH2:11][C:12]([O:14]C)=[O:13])[C:4](=[O:16])[C:3]2=[CH:17][CH:18]=[CH:19][CH:20]=[C:2]12>Cl.CC(C)=O.O>[C:4]1(=[O:16])[N:5]([CH2:6][C:7]#[C:8][CH2:9][CH2:10][CH2:11][C:12]([OH:14])=[O:13])[C:1](=[O:21])[C:2]2=[CH:20][CH:19]=[CH:18][CH:17]=[C:3]12

참가 물질

5

반응물 1

HCID 20066955Methyl 7-phthalimidohept-5-ynoate

생성물 1

HCID 154705147-Phthalimidohept-5-ynoic Acid수율 81.2%

시약·촉매·용매 3

HCID 180Acetone용매HCID 313Hydrochloric Acid용매HCID 962Water용매2회

실험 절차

Methyl 7-phthalimidohept-5-ynoate (1.45 g) was dissolved in a mixture of concentrated hydrochloric acid (7.3 ml), acetone (30 ml) and water (14.6 ml) and the resulting solution was heated at reflux for 3.5 hours. The solution was cooled and then poured into water (175 ml). The precipitate was collected by filtration and recrystallised from ethanol-water to give the title compound (1.12 g) m.p. 120°-122° C.

후처리

  1. temperaturethe resulting solution was heated
  2. temperatureat reflux for 3.5 hours
  3. temperatureThe solution was cooled
  4. filtrationThe precipitate was collected by filtration
  5. customrecrystallised from ethanol-water

출처 및 근거

ORD 기록
ord-d5c0e32b8e5c4f339814a1b6d66005ad
출처 데이터셋
uspto-grants-1991_03
특허 번호
US04997847

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