Hydrazine hydrate (1:1) → 7-Aminohept-5-ynoic Acid

HRID 358620노트

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HRID 358620 반응식
O.NN.C1(=O)[N:8]([CH2:9][C:10]#[C:11][CH2:12][CH2:13][CH2:14][C:15]([OH:17])=[O:16])C(=O)C2=CC=CC=C12>C(O)C>[NH2:8][CH2:9][C:10]#[C:11][CH2:12][CH2:13][CH2:14][C:15]([OH:17])=[O:16]

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 154705147-Phthalimidohept-5-ynoic Acid

생성물 1

HCID 200669627-Aminohept-5-ynoic Acid수율 66.4%

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
5 °C

실험 절차

Hydrazine hydrate (0.1 ml) was added to a solution of 7-phthalimidohept-5-ynoic acid (0.55 g) in ethanol (25 ml). The mixture was refluxed for 3.5 hours and then the solvent was removed under reduced pressure. The residue was suspended in water (20 ml), the pH of the solution was adjusted to 5, and the solid was collected by filtration. The filtrate was evaporated to dryness and the residue was extracted with ethanol (3×5 ml). The ethanol extracts were cooled (5° C.) and the resulting precipitate was collected to give the title compound (0.19 g) m.p. 180°-183° C.

후처리

  1. temperatureThe mixture was refluxed for 3.5 hours
  2. customthe solvent was removed under reduced pressure
  3. filtrationthe solid was collected by filtration
  4. customThe filtrate was evaporated to dryness
  5. extractionthe residue was extracted with ethanol (3×5 ml)
  6. customthe resulting precipitate was collected

출처 및 근거

ORD 기록
ord-f3efc93560af4e3485c6e2496ad49052
출처 데이터셋
uspto-grants-1991_03
특허 번호
US04997847

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