2-Phenylbutyric Acid → Methyl 3-methoxy-4-[2,3,5-trimethyl-6-(2-phenylbutanamido)indol-1-ylmethyl]-benzoate

HRID 358738

반응식

HRID 358738 반응식
[NH2:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:25])=[C:7]([CH3:24])[N:8]2[CH2:11][C:12]2[CH:21]=[CH:20][C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:14][C:13]=2[O:22][CH3:23])=[CH:4][C:3]=1[CH3:26].CC1NC2C(C=1C)=CC(C)=C([N+]([O-])=O)C=2.[C:42]1([CH:48]([CH2:52][CH3:53])[C:49](O)=[O:50])[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1>>[CH3:23][O:22][C:13]1[CH:14]=[C:15]([CH:20]=[CH:21][C:12]=1[CH2:11][N:8]1[C:9]2[C:5](=[CH:4][C:3]([CH3:26])=[C:2]([NH:1][C:49](=[O:50])[CH:48]([C:42]3[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=3)[CH2:52][CH3:53])[CH:10]=2)[C:6]([CH3:25])=[C:7]1[CH3:24])[C:16]([O:18][CH3:19])=[O:17]

참가 물질

4

반응물 3

HCID 70122-Phenylbutyric AcidHCID 6093282,3,5-Trimethyl-6-nitro-1H-indoleHCID 19744303Methyl 4-(6-amino-2,3,5-trimethylindol-1-ylmethyl)-3-methoxybenzoate

생성물 1

HCID 19744308Methyl 3-methoxy-4-[2,3,5-trimethyl-6-(2-phenylbutanamido)indol-1-ylmethyl]-benzoate수율 32%

실험 절차

Similarly, starting from methyl 4-(6-amino-2,3,5-trimethylindol-1-ylmethyl)-3-methoxybenzoate (itself obtained using the procedures described for A in Example 1 but starting from 2,3,5-trimethyl-6-nitroindole [G]) and 2-phenylbutyric acid, there was obtained methyl 3-methoxy-4-[2,3,5-trimethyl-6-(2-phenylbutanamido)indol-1-ylmethyl]benzoate [Example 83] in 32% yield as a white solid; partial NMR: 0.9 (t,3H,CH2CH3), 1.2 (m,2H, CH2CH3), 3.4 (t,1H,CHPh), 7.3 (s,5H,Ph).

후처리

  1. customobtained

출처 및 근거

ORD 기록
ord-dbd3a55b4fd647e29aeb556cbbd9f713
출처 데이터셋
uspto-grants-1991_03
특허 번호
US04997844

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